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During postmarketing use, there have been reports of clinically significant drug interactions in patients receiving fluticasone propionate products, including FLONASE, with ritonavir, resulting in systemic flonase corticosteroid effects including Cushing’s syndrome and adrenal suppression . A drug interaction trial with fluticasone propionate aqueous nasal spray in healthy subjects has shown that ritonavir (a strong CYP3A4 inhibitor) flonase can significantly increase plasma fluticasone propionate exposure, resulting in significantly reduced serum cortisol concentrations [see CLINICAL PHARMACOLOGY] .
Table 1: flonase Adverse Reactions with FLONASE Nasal Spray with > 3% Incidence and More Common than Placebo in Subjects ? 4 Years with Allergic Rhinitis .
flonase Adverse Reaction FLONASE 100 mcg .

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